Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury

Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury

Blog Article

Secondary spinal cord injury (SSCI) is the second stage of spinal cord injury (SCI) and involves vasculature derangement, immune response, inflammatory response, and glial scar formation.Bioactive additives, such as drugs and cells, have been widely used to inhibit the progression of secondary spinal cord injury.However, the delivery and long-term retention of T-shirt these additives remain a problem to be solved.

In recent years, hydrogels have attracted much attention as a popular delivery system for loading cells and drugs for secondary spinal cord injury therapy.After implantation into the site of spinal cord injury, hydrogels can deliver bioactive additives in situ and induce the unidirectional growth of nerve cells as scaffolds.In addition, physical and chemical methods can endow hydrogels with new functions.

In this review, we summarize the current state of various hydrogel delivery systems for secondary spinal cord injury treatment.Moreover, functional modifications of these hydrogels for better therapeutic effects are also discussed Hood to provide a comprehensive insight into the application of hydrogels in the treatment of secondary spinal cord injury.